Available positions: 1 x Technician, 1 x Postdoc
posted 20 July 2020
We are looking for a technician and postdoc to work a joint project between the Laboratory of Applied Evolutionary Biology of the Amsterdam University Medical Center (location AMC) and the Department of Pathology of the University of Cambridge. The appointed technician and postdoc will work on a ZonMW/NWO funded project to develop a high-throughput SARS-CoV-2 replication assay that can be used under standard biosafety laboratory conditions.
The COVID-19 pandemic demonstrates how underprepared the world has been for emerging pandemic respiratory viruses, such as SARS-CoV-2. Although European countries have now brought down the number of active infections by enforcing lockdowns and are allowing international travel again, SARS-CoV-2 is still actively spreading and a second COVID-19 wave is likely to hit European countries this fall. In order to treat people prophylactically as well as people already infected with SARS-CoV-2 when the second wave hits, new (orally available) antivirals are urgently needed. Currently, no such antiviral is approved for the treatment of people infected with SARS-CoV-2 or treatment people prophylactically. Screening for new SARS-CoV-2 antiviral is currently restricted to a special containment laboratory (BSL3+), which limits throughput and slows down antiviral discovery and optimisation.
The technician and postdoc will be primarily responsible for the development of the SARS-CoV-2 replication activity assay, the screening of putative inhibitor libraries, and the validation of candidate antivirals using in vitro and virus assays. There will be ample opportunities to develop other skills and contribute to multiple aspects of the project. Previous experience with molecular cloning and cell culture is essential. Experience with BSL-3 experiments, polymerase assays, or drug screening is desirable. These positions are available for one year, but extensions may be offered if further funding is found.
Position is full time (36 hours/week, 1.0 FTE) and available from 01 September 2020.
Applications will be considered as they are received and the position remains open as long as this ad is viewable.
Salary is by experience according to the Dutch UMC CAO (the collective bargaining agreement that dictates salaries at all Dutch University Medical Centers).